AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Mar 16, 2011 16:58:39  |  Visits:2581  |  Runs:56
Free Keywords: Single neuron, Action potential back-propagation, Somatic spike, Spike i nitiation
ID 144
Title AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)
Free Keywords Single neuron, Action potential back-propagation, Somatic spike, Spike i nitiation
Description These model files were for the paper:

Yu Y.G., Shu Y., Duque A., Haider B., and McCormick D.A.
Cortical Action Potential Back-propagation Explains Spike Threshold
Variability and Rapid-Onset Kinetics.
Journal of Neuroscience, 28: 7260-7272, (2008).

and also

McCormick D.A., Shu Y., and Yu Y.G.
Neurophysiology: Hodgkin and Huxley model - still standing?
Nature. 445: E1-E2, (2007).

This simple axon-soma model explained how the rapid rising phase in
somatic spike is derived from propagated axon initiated spike.

Creates a single cell containing a dendrite, soma, an axon with 60
micrometer and a axon bleb to investigate generation of spike kink at
soma. As observed in experiment, spikes are usually initiated at the
axon site 40~70 micrometer away from soma. There is a rapid rising
phase in somatic spike, due to the initial segment traveling spike.

After running the code, there is an output data file called
'neuron_soma.dat' Use the matlab code for_plot_spike.m to plot the
somatic spike and axon spike.

These files were contributed by
Yuguo Yu
Yale University


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Last Modified Date Mar 25, 2013 11:56:39
Created Date Mar 16, 2011 16:58:39
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
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Mar 25, 2013 Modified; Contents URL.
Feb 12, 2012 Modified; Description.
Feb 12, 2012 Modified; Description, Free Keywords, Simulator Name.
Mar 24, 2011 Modified; Index.
Mar 23, 2011 Modified; Preview, Simulator.
Model Contents URL http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=135839
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Simulator Name Neuron
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