AP initiation and propagation in type II cochlear ganglion cell (Hossain et al 2005)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Mar 16, 2011 17:00:13  |  Visits:2137  |  Runs:42
Free Keywords: initial segment, spiral ganglion, cochlear nucleus, hair cells, quivering mutation
ID 145
Title AP initiation and propagation in type II cochlear ganglion cell (Hossain et al 2005)
Free Keywords initial segment, spiral ganglion, cochlear nucleus, hair cells, quivering mutation
Description The model of type II cochlear ganglion cell was based on the immunostaining of the mouse auditory pathway. Specific antibodies were used to map the distribution of voltage-dependent sodium channels along the two unmyelinated axon-like processes of the bipolar ganglion cells. Three distinct hot spots were detected. A high density of sodium channels was present over the entire trajectory of sensory endings beneath the outer hair cells (the most distal portion of the peripheral axon). THE other two hot spots were localized in the initial segments of both of the axons that flank the unmyelinated bipolar ganglion cell bodies.

A biophysical model indicates that all three hot spots might play important roles in action potential initiation and propagation. For instance, the hot spot in the receptor segment is important for transforming the receptor potentials into a full blown action potential (Supplemental Fig. 1). The hot spots in the two paraganglionic axon initial segments are there to ensure the successful propagation of action potentials from the peripheral to the central axon through the cell body.

Result: The sesstion files should be selected by GUI->File for simulation.
Last Modified Date Mar 25, 2013 13:12:00
Created Date Mar 16, 2011 17:00:13
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Mar 25, 2013 Modified; Contents URL.
Feb 2, 2012 Modified; Description, Free Keywords, Simulator Name.
Mar 24, 2011 Modified; Index.
Mar 23, 2011 Modified; Preview, Simulator.
Model Contents URL http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=54903
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Model Site Name ModelDB
Simulator Name Neuron
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