Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Mar 16, 2011 17:10:29  |  Visits:1665  |  Runs:9
Free Keywords: Cerebellum, Golgi cell, Alchol, Excitability
ID 152
Title Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)
Free Keywords Cerebellum, Golgi cell, Alchol, Excitability
Description /*******Cerebellar Golgi Cell Model with Na+/K+ ATPase**********

Developers: Fabio M Simoes de Souza & E De Schutter

Work Progress: July 2009 - Dec 2009

Developed At: Okinawa Institute of Science and Technology
Computational Neuroscience Unit
Okinawa - Japan

Model Published in:

Botta P, Simoes de Souza F, Sangrey T, De Schutter E,
Valenzuela F (2010) Alcohol excites cerebellar Golgi
cells by inhibiting the Na+/K+ ATPase.
Neuropsychopharmacology 35: 1984-1996.

This script is a modification from a previous published GoC model
(Solinas et al., 2007). A Na+/K+ ATPase and ionic concentration pools
for Na+, K+, Ca2+ were incorporated into the soma of the model.
The equations that simulated the Na+/K+ ATPase are described in Table
S10 of Takeuchi et al. (2006)

Abstract

Alcohol Excites Cerebellar Golgi Cells by Inhibiting the Na+/K+ ATPase
Patch-clamp in cerebellar slices and computer modeling show that
ethanol excites Golgi cells by inhibiting the Na+/K+ ATPase. In
particular, voltage-clamp recordings of Na+/K+ ATPase currents
indicated that ethanol partially inhibits this pump and this effect
could be mimicked by low concentrations of the Na+/K+ ATPase blocker
ouabain. The partial inhibition of Na+/K+ ATPase in a computer model
of the Golgi cell reproduced these experimental findings that
established a novel mechanism of action of ethanol on neural
excitability.

Reference: Botta P, de Souza FM, Sangrey T, De Schutter E, Valenzuela
CF (2010) Alcohol excites cerebellar Golgi cells by inhibiting the
na(+)-k(+) ATPase. Neuropsychopharmacology 35:1984-96

Usage instructions:

Auto-launch from ModelDB or download and extract the archive. Then
under:

----
MSWIN

run mknrndll, cd to the archive and make the nrnmech.dll. Then double
click on the mosinit.hoc file.

----
MAC OS X

Drag and drop the Golgi_cell_NaKATPAse folder onto the mknrndll icon.
Drag and drop the mosinit.hoc file onto the nrngui icon.

----
Linux/Unix

Change directory to the Golgi_cell_NaKATPAse folder. run
nrnivmodl. Then type nrngui mosinit.hoc

----

Once the simulation is started click the button labeled
"Figure 7g from Botta et al. 2010" The simulation will produce a
result similar to figure 7g from the paper:
Last Modified Date Mar 25, 2013 14:38:25
Created Date Mar 16, 2011 17:10:29
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Mar 25, 2013 Modified; Contents URL.
Feb 12, 2012 Modified; Description, Free Keywords, Simulator Name.
Mar 24, 2011 Modified; Index.
Mar 23, 2011 Modified; Preview, Simulator.
Model Contents URL http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=127021
Hits:0
Model Site Name ModelDB
Simulator Name Neuron
Simulator Version
Index
/ Public / Title / A-E


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