Fast-spiking cortical interneuron (Golomb et al. 2007)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Mar 17, 2011 14:29:25  |  Visits:2145  |  Runs:58
Free Keywords: Action Potentials, Animals, Computer Simulation, Humans, Interneurons, Neurological Models, Neocortex, Nerve Net, Neural Inhibition, Synaptic Transmission
ID 246
Title Fast-spiking cortical interneuron (Golomb et al. 2007)
Free Keywords Action Potentials, Animals, Computer Simulation, Humans, Interneurons, Neurological Models, Neocortex, Nerve Net, Neural Inhibition, Synaptic Transmission
Description Cortical fast-spiking (FS) interneurons display highly variable electrophysiological properties. We hypothesize that this variability emerges naturally if one assumes a continuous distribution of properties in a small set of active channels. We construct a minimal, single-compartment conductance-based model of FS cells that includes transient Na+, delayed-rectifier K+, and slowly inactivating d-type K+ conductances. The model may display delay to firing. Stuttering (elliptic bursting) and subthreshold oscillations may be observed for small Na+ window current.

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Initialconds -> (G)o

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Reference:
Golomb D, Donner K, Shacham L, Shlosberg D, Amitai Y, Hansel D (2007) Mechanisms of Firing Patterns in Fast-Spiking Cortical Interneurons. PLoS Comput Biol 3:e156-
Last Modified Date Mar 22, 2013 13:11:40
Created Date Mar 17, 2011 14:29:25
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Mar 22, 2013 Modified; Contents URL.
Feb 24, 2012 Modified; Description, Free Keywords, Simulator Name.
Mar 24, 2011 Modified; Index.
Mar 23, 2011 Modified; Preview, Simulator.
Model Contents URL http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=97747
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Model Site Name ModelDB
Simulator Name Neuron, XPP
Simulator Version
Index
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