Supported by INCF Japan NodeFast-spiking cortical interneuron (Golomb et al. 2007)
Contributor:NIJC Administrator (nijcadmin)
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Created Date: Mar 17, 2011 14:29:25
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Visits:1929
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Runs:56
Free Keywords: Action Potentials, Animals, Computer Simulation, Humans, Interneurons, Neurological Models, Neocortex, Nerve Net, Neural Inhibition, Synaptic Transmission
| ID | 246 | ||||||||
| Title | Fast-spiking cortical interneuron (Golomb et al. 2007) | ||||||||
| Free Keywords | Action Potentials, Animals, Computer Simulation, Humans, Interneurons, Neurological Models, Neocortex, Nerve Net, Neural Inhibition, Synaptic Transmission | ||||||||
| Description | Cortical fast-spiking (FS) interneurons display highly variable electrophysiological properties. We hypothesize that this variability emerges naturally if one assumes a continuous distribution of properties in a small set of active channels. We construct a minimal, single-compartment conductance-based model of FS cells that includes transient Na+, delayed-rectifier K+, and slowly inactivating d-type K+ conductances. The model may display delay to firing. Stuttering (elliptic bursting) and subthreshold oscillations may be observed for small Na+ window current. Start the simulation by clicking on Initialconds -> (G)o You will see a reproduction of fig2c. Reference: Golomb D, Donner K, Shacham L, Shlosberg D, Amitai Y, Hansel D (2007) Mechanisms of Firing Patterns in Fast-Spiking Cortical Interneurons. PLoS Comput Biol 3:e156- |
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| Last Modified Date | Mar 22, 2013 13:11:40 | ||||||||
| Created Date | Mar 17, 2011 14:29:25 | ||||||||
| Contributor | NIJC Administrator (nijcadmin) | ||||||||
| Item Type | Online Simulation | ||||||||
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| Model Contents URL |
http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=97747
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| Model Site Name | ModelDB | ||||||||
| Simulator Name | Neuron, XPP | ||||||||
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