Fluctuating synaptic conductances recreate in-vivo-like activity (Destexhe et al 2001)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Mar 17, 2011 14:34:34  |  Visits:1958  |  Runs:48
Free Keywords: Action Potentials, Animals, Cats, Cell Compartmentation, Dendrites, Glutamic Acid, Ion Channels, Neurological Models, Neocortex, Nerve Net, Neural Inhibition, Organ Culture Techniques, Patch-Clamp Techniques, Pyramidal Cells, Sprague-Dawley Rats, AMPA/drug effects Receptors, AMPA/physiology Receptors, Stochastic Processes, Synapses, Synaptic Transmission, Tetrodotoxin, gamma-Aminobutyric Acid
ID 249
Title Fluctuating synaptic conductances recreate in-vivo-like activity (Destexhe et al 2001)
Free Keywords Action Potentials, Animals, Cats, Cell Compartmentation, Dendrites, Glutamic Acid, Ion Channels, Neurological Models, Neocortex, Nerve Net, Neural Inhibition, Organ Culture Techniques, Patch-Clamp Techniques, Pyramidal Cells, Sprague-Dawley Rats, AMPA/drug effects Receptors, AMPA/physiology Receptors, Stochastic Processes, Synapses, Synaptic Transmission, Tetrodotoxin, gamma-Aminobutyric Acid
Description This model (and experiments) reported in Destexhe, Rudolh, Fellous, and Sejnowski (2001) support the hypothesis that many of the characteristics of cortical neurons in vivo can be explained by fast glutamatergic and GABAergic conductances varying stochastically. Some of these cortical neuron characteristics of fluctuating synaptic origin are a depolarized membrane potential, the presence of high-amplitude membrane potential fluctuations, a low input resistance and irregular spontaneous firing activity. In addition, the point-conductance model could simulate the enhancement of responsiveness due to background activity. For more information please contact Alain Destexhe. email: Destexhe@iaf.cnrs-gif.fr

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Reference:
Destexhe A, Rudolph M, Fellous JM, Sejnowski TJ (2001) Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons. Neuroscience 107:13-24
Last Modified Date Mar 22, 2013 13:07:51
Created Date Mar 17, 2011 14:34:34
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Mar 22, 2013 Modified; Contents URL.
Feb 24, 2012 Modified; Description, Free Keywords, Simulator Name.
Mar 24, 2011 Modified; Index.
Mar 23, 2011 Modified; Preview, Simulator.
Model Contents URL http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=8115
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Model Site Name ModelDB
Simulator Name Neuron
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Index
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