Fluctuating synaptic conductances recreate in-vivo-like activity (Destexhe et al 2001)

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登録者:NIJC管理者 (nijcadmin)  |  作成日: Mar 17, 2011 14:34:34  |  来訪者数:2100  |  実行回数:49
フリーキーワード: Action Potentials, Animals, Cats, Cell Compartmentation, Dendrites, Glutamic Acid, Ion Channels, Neurological Models, Neocortex, Nerve Net, Neural Inhibition, Organ Culture Techniques, Patch-Clamp Techniques, Pyramidal Cells, Sprague-Dawley Rats, AMPA/drug effects Receptors, AMPA/physiology Receptors, Stochastic Processes, Synapses, Synaptic Transmission, Tetrodotoxin, gamma-Aminobutyric Acid
ID 249
タイトル Fluctuating synaptic conductances recreate in-vivo-like activity (Destexhe et al 2001)
フリーキーワード Action Potentials, Animals, Cats, Cell Compartmentation, Dendrites, Glutamic Acid, Ion Channels, Neurological Models, Neocortex, Nerve Net, Neural Inhibition, Organ Culture Techniques, Patch-Clamp Techniques, Pyramidal Cells, Sprague-Dawley Rats, AMPA/drug effects Receptors, AMPA/physiology Receptors, Stochastic Processes, Synapses, Synaptic Transmission, Tetrodotoxin, gamma-Aminobutyric Acid
概要 This model (and experiments) reported in Destexhe, Rudolh, Fellous, and Sejnowski (2001) support the hypothesis that many of the characteristics of cortical neurons in vivo can be explained by fast glutamatergic and GABAergic conductances varying stochastically. Some of these cortical neuron characteristics of fluctuating synaptic origin are a depolarized membrane potential, the presence of high-amplitude membrane potential fluctuations, a low input resistance and irregular spontaneous firing activity. In addition, the point-conductance model could simulate the enhancement of responsiveness due to background activity. For more information please contact Alain Destexhe. email: Destexhe@iaf.cnrs-gif.fr

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Reference:
Destexhe A, Rudolph M, Fellous JM, Sejnowski TJ (2001) Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons. Neuroscience 107:13-24
最終更新日 Mar 22, 2013 13:07:51
作成日 Mar 17, 2011 14:34:34
登録者 NIJC管理者 (nijcadmin)
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Mar 22, 2013 Modified; Contents URL.
Feb 24, 2012 Modified; Description, Free Keywords, Simulator Name.
Mar 24, 2011 Modified; Index.
Mar 23, 2011 Modified; Preview, Simulator.
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