Kinetic NMDA receptor model (Kampa et al 2004)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Mar 17, 2011 15:00:54  |  Visits:2032  |  Runs:116
Free Keywords: NMDA, pyramidal cell
ID 269
Title Kinetic NMDA receptor model (Kampa et al 2004)
Free Keywords NMDA, pyramidal cell
Description Based on voltage-clamp recordings of NMDA receptor-mediated currents in nucleated patches of rat neocortical layer 5 pyramidal neurons (Kampa 2004), this model was fit with AxoGraph directly to experimental recordings in order to obtain the optimal values for the parameters. The NMDA receptor model uses realistic rates of magnesium block and its effects on channel desensitisation. Presynaptic transmitter release is necessary for glutamate binding to the receptor.

Auto run reproduces the behaviour of a kinetic NMDA receptor model reproducing the data in figure 2 in Kampa et al (2004) J Physiol.
Last Modified Date Mar 22, 2013 09:25:28
Created Date Mar 17, 2011 15:00:54
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Mar 22, 2013 Modified; Contents URL.
Feb 2, 2012 Modified; Description, Free Keywords, Simulator Name.
Mar 24, 2011 Modified; Index.
Mar 23, 2011 Modified; Preview, Simulator.
Model Contents URL http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=50207
Hits:1
Model Site Name ModelDB
Simulator Name Neuron
Simulator Version
Index
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