Temperature-Sensitive conduction at axon branch points (Westerfield et al 1978)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Feb 24, 2015 14:55:23  |  Visits:1410  |  Runs:2
Free Keywords: Axonal Action Potentials, Conduction failure
ID 541
Title Temperature-Sensitive conduction at axon branch points (Westerfield et al 1978)
Free Keywords Axonal Action Potentials, Conduction failure
Description This model reproduces figure 2C & 2D. An action potential, generated in the
small (40 um) branch, fails to invade the large axon (250 um) on the first
run at 7 degC but does invade when the temperature is reduced to 5 degC for
the second run. As discussed in the paper, the experimental values for the
amplitude and rate of rise of the action potential were quite dependent on the
physiological condition of the axon. The same is true for the value of the
critical temperature as can be seen in the simulation when the initial condition
(resting potential) is altered. For this simulation the resting potential
was depolarised from -65 to -64 mV as a consequence of changing the leakage
reversal potential from el_hh = -50.183629 to -54.401079 (see the
init procedure in the mosinit.hoc file).
Last Modified Date Feb 24, 2015 14:57:39
Created Date Feb 24, 2015 14:55:23
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Feb 24, 2015 タイトル, プレビュー を変更
Model Contents URL https://senselab.med.yale.edu/modeldb/ShowModel.asp?model=9849
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