Thalamic interneuron multicompartment model (Zhu et al. 1999)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Feb 24, 2015 15:00:13  |  Visits:1410  |  Runs:8
Free Keywords: Bursting, Oscillations
ID 542
Title Thalamic interneuron multicompartment model (Zhu et al. 1999)
Free Keywords Bursting, Oscillations
Description By using the whole cell patch recording technique in vitro, the voltage-dependent firing patterns in the rat dorsal lateral geniculate nucleus (LGN) were measured. When held at a hyperpolarized membrane potential, all interneurons responded with a burst of action potentials. In 48 interneurons, larger current pulses produced a bursting oscillation. When relatively depolarized, some interneurons produced a tonic train of action potentials in response to a depolarizing current pulse. However, most interneurons produced only oscillations, regardless of polarization level.

The oscillation was insensitive to the bath application of a combination of blockers to excitatory and inhibitory synaptic transmission, including 30 microM 6,7-dinitroquinoxaline-2,3-dione, 100 microM (+/-)-2-amino-5-phosphonopentanoic acid, 20 microM bicuculline, and 2 mM saclofen, suggesting an intrinsic event. The frequency of the oscillation in interneurons was dependent on the intensity of the injection current. Increasing current intensity increased the oscillation frequency. The maximal frequency of the oscillation was 5-15 Hz for most cells, with some ambiguity caused by the difficulty of precisely defining a transition from oscillatory to regular firing behavior. In contrast, the interneuron oscillation was little affected by preceding depolarizing and hyperpolarizing pulses. In addition to being elicited by depolarizing current injections, the oscillation could also be initiated by electrical stimulation of the optic tract when the interneurons were held at a depolarized membrane potential. This suggests that interneurons may be recruited into thalamic oscillations by synaptic inputs. These results indicate that interneurons may play a larger role in thalamic oscillations than was previously thought.

The model registered in this server is able to get something that looks generally like a physiological trace in J Neurophysiol, 81:702--711, 1999, Fig. 8b top trace. Please execute and have a look. Simulation can execute by clicking "click here to run" button.
Last Modified Date May 17, 2016 13:12:17
Created Date Feb 24, 2015 15:00:13
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
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May 17, 2016 Modified; Description.
Feb 24, 2015 プレビュー を変更
Feb 24, 2015 概要, フリーキーワード, コンテンツへのURL, モデルコンテンツへのURL を変更
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