T-type Calcium currents (McRory et al 2001)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Feb 14, 2017 11:16:46  |  Visits:733  |  Runs:1
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ID 576
Title T-type Calcium currents (McRory et al 2001)
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Description NEURON mod files for CaT currents from the paper:
McRory et al., J.Biol.Chem. 276:3999 (2001).

Running the kinetics.hoc simulation file will show
the activation and inactivation steady-states and time constants
of the three members of the LVA calcium channels family studied
in this paper (alpha-1G, -1H, and -1I), with kinetic parameters
from functional expression in transfected cells.

Parameters for activation/inactivation are from the paper.
However, not all the parameters used to fit (with single exponentials)
the experimental values for the time constants were given in the paper.
Those explicitly reported were used to constrain a fit
of experimental values derived from Fig.6.

Ca++ reversal potential is calculated from Nerst equation, using
internal and external Ca++ concentrations.
Default values are [Ca]i=50nM and [Ca]o=2mM.
Last Modified Date Mar 23, 2017 11:12:06
Created Date Feb 14, 2017 11:16:46
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Mar 23, 2017 インデックス を変更
Model Contents URL https://senselab.med.yale.edu/modeldb/ShowModel.asp?model=19920
Model Site Name ModelDB
Simulator Name Neuron
Simulator Version
/ Public / Title / T-X

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