CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Jan 11, 2018 15:13:55  |  Visits:614  |  Runs:3
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ID 685
Title CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
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Description R213W and R213Q mutations markedly destabilized the open state, causing a dramatic decrease in channel voltage sensitivity. Modeling these channels in CA1 hippocampal pyramidal cells revealed that both mutations increased cell firing frequency, with the R213Q mutation prompting more dramatic functional changes compared with the R213W mutation.

This is a simulation for difference of responses caused by mutation in the voltage sensor of Kv7.2. You can select mutation and click run button to start simulation.

Reference:
Miceli F, Soldovieri MV, Ambrosino P, Barrese V, Migliore M, Cilio MR, Taglialatela M (2013) Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of Kv7.2 potassium channel subunits. Proc Natl Acad Sci U S A 110(11):4386-91
Last Modified Date Jan 11, 2018 20:18:26
Created Date Jan 11, 2018 15:13:55
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Jan 11, 2018 Modified; Description, Index, Preview.
Model Contents URL https://senselab.med.yale.edu/ModelDB/showModel.cshtml?model=148094
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Model Site Name ModelDB
Simulator Name Neuron
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