CA1 pyramidal neuron: Ih current (Migliore et al. 2012)

Add this entry.

Bookmark this on Yahoo Bookmark
Bookmark this on Delicious
Bookmark this on Google Bookmarks
Bookmark this on BuzzURL
Share on StumbleUpon
Share on GREE
Bookmark this on Livedoor Clip
Add Browser Bookmark

vDesktop Size:

Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Jan 11, 2018 16:55:41  |  Visits:358  |  Runs:4
Free Keywords: 
ID 686
Title CA1 pyramidal neuron: Ih current (Migliore et al. 2012)
Free Keywords
Description The non-specific, hyperpolarization activated, Ih current is
particularly involved in epilepsy and it exhibits an excitatory or
inhibitory action on synaptic integration in an apparently
inconsistent way. With a series of simulations, using a realistic
model, This model shows how and why a shunting current, such as that carried by TASK-like channels, dependent on the Ih peak conductance, is able to explain virtually all experimental findings on Ih up- or
down-regulation by modulators or pathological conditions.

Simulation will start by clicking run button in the nrniv window.

Reference:
Migliore M, Migliore R (2012) Know your current I: interaction with a shunting current explains the puzzling effects of its pharmacological or pathological modulations PLoS One 7(5):e36867
Last Modified Date Feb 8, 2018 13:18:14
Created Date Jan 11, 2018 16:55:41
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Feb 8, 2018 Modified; Index.
Feb 8, 2018 Modified; Description, Preview.
Model Contents URL https://senselab.med.yale.edu/ModelDB/showModel.cshtml?model=144541
Hits:2
Model Site Name ModelDB
Simulator Name Neuron
Simulator Version
Index
/ Public


Online Users
3 user(s) are online (2 user(s) are browsing Database)

Members: 0
Guests: 3

more...
Related Items