CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Jan 11, 2018 19:52:08  |  Visits:475  |  Runs:2
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ID 689
Title CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
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Description This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.

Simulation will be started by clicking BPAP run button in the Control panel.

Reference:
Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy PLoS Comput Biol 8(6):e1002545
Last Modified Date Feb 8, 2018 13:50:07
Created Date Jan 11, 2018 19:52:08
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Feb 8, 2018 Modified; Description, Preview.
Feb 8, 2018 Modified; Index.
Feb 8, 2018 Modified; Description, Model Contents URL.
Model Contents URL https://senselab.med.yale.edu/modeldb/ShowModel.cshtml?model=144490
Hits:3
Model Site Name ModelDB
Simulator Name Neuron
Simulator Version
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