Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)

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Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Jan 16, 2018 04:13:51  |  Visits:542  |  Runs:4
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ID 698
Title Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
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Description This is an electric compartment model of the striatal medium spiny neuron with a realistic morphology and predict the calcium responses in the synaptic spines with variable timings of the glutamatergic and dopaminergic inputs and the postsynaptic action potentials. The model was validated by reproducing the responses to current inputs and could predict the electric and calcium responses to glutamatergic inputs and back-propagating action potential in the proximal and distal synaptic spines during up and down states.

To run the simulation, to click iniit & run button in the RunControl window after setting current stimulus in the PointProcessManager window.

Reference:
1 . Nakano T, Yoshimoto J, Doya K (2013) A model-based prediction of the calcium responses in the striatal synaptic spines depending on the timing of cortical and dopaminergic inputs and post-synaptic spikes. Front Comput Neurosci 7:119
Last Modified Date Jan 19, 2018 19:16:58
Created Date Jan 16, 2018 04:13:51
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Jan 19, 2018 Modified; Description, Index.
Jan 19, 2018 Modified; Description, Preview.
Model Contents URL https://senselab.med.yale.edu/ModelDB/showModel.cshtml?model=151458
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Model Site Name ModelDB
Simulator Name Neuron
Simulator Version
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