Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)

Add this entry.

Bookmark this on Yahoo Bookmark
Bookmark this on Delicious
Bookmark this on Google Bookmarks
Bookmark this on BuzzURL
Share on StumbleUpon
Share on GREE
Bookmark this on Livedoor Clip
Add Browser Bookmark

vDesktop Size:

Contributor:NIJC Administrator (nijcadmin)  |  Created Date: Mar 16, 2011 16:06:53  |  Visits:1683  |  Runs:8
Free Keywords: Dendritic Action Potential, Active Dendrite, Electrosensory Lateral Line Lobe, Electric Fish
ID 82
Title Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)
Free Keywords Dendritic Action Potential, Active Dendrite, Electrosensory Lateral Line Lobe, Electric Fish
Description Many central neurons support active dendritic spikebackpropagation mediated by voltage-gated currents. Active spikesin dendrites have been shown capable of providing feedback to thesoma to influence somatic excitability and firing dynamicsthrough a depolarizing afterpotential (DAP). In pyramidal cellsof the electrosensory lobe of weakly electric fish, Na(+) spikesin dendrites undergo a frequency-dependent broadening thatenhances the DAP to increase somatic firing frequency. We use acombination of dynamical analysis and electrophysiologicalrecordings to demonstrate that spike broadening in dendrites isprimarily caused by a cumulative inactivation of dendritic Na(+)current. We further show that a reduction in dendritic Na(+)current increases excitability by decreasing the interspikeinterval and promoting burst firing. This process arises wheninactivation of dendritic Na(+) current shifts the latency of thedendritic spike to delay the arrival of the DAP sufficiently toincrease its impact on somatic membrane potential despite areduction in dendritic excitability. Furthermore, therelationship between dendritic Na(+) current density and somaticexcitability is nonmonotonic, as intermediate levels of dendriticNa(+) current exert the greatest excitatory influence. Theseresults reveal that temporal shifts in dendritic spike firingprovide a novel means for backpropagating spikes to influence thefinal output of a cell.

After the completing the simulation, Fig.2B in Fernandez et al, JNP2005 is shown up.
Last Modified Date Mar 22, 2013 10:49:09
Created Date Mar 16, 2011 16:06:53
Contributor NIJC Administrator (nijcadmin)
Item Type Online Simulation
Change Log(History)
Mar 22, 2013 Modified; Contents URL.
Feb 2, 2012 Modified; Description, Free Keywords, Simulator Name.
Mar 24, 2011 Modified; Index.
Mar 23, 2011 Modified; Preview, Simulator.
Model Contents URL http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=59480
Hits:0
Model Site Name ModelDB
Simulator Name MATLAB
Simulator Version
Index
/ Public / Title / A-E


Online Users
8 user(s) are online (8 user(s) are browsing Database)

Members: 0
Guests: 8

more...
Related Items