Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)

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登録者:NIJC管理者 (nijcadmin)  |  作成日: Mar 16, 2011 16:06:53  |  来訪者数:1813  |  実行回数:8
フリーキーワード: Dendritic Action Potential, Active Dendrite, Electrosensory Lateral Line Lobe, Electric Fish
ID 82
タイトル Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)
フリーキーワード Dendritic Action Potential, Active Dendrite, Electrosensory Lateral Line Lobe, Electric Fish
概要 Many central neurons support active dendritic spikebackpropagation mediated by voltage-gated currents. Active spikesin dendrites have been shown capable of providing feedback to thesoma to influence somatic excitability and firing dynamicsthrough a depolarizing afterpotential (DAP). In pyramidal cellsof the electrosensory lobe of weakly electric fish, Na(+) spikesin dendrites undergo a frequency-dependent broadening thatenhances the DAP to increase somatic firing frequency. We use acombination of dynamical analysis and electrophysiologicalrecordings to demonstrate that spike broadening in dendrites isprimarily caused by a cumulative inactivation of dendritic Na(+)current. We further show that a reduction in dendritic Na(+)current increases excitability by decreasing the interspikeinterval and promoting burst firing. This process arises wheninactivation of dendritic Na(+) current shifts the latency of thedendritic spike to delay the arrival of the DAP sufficiently toincrease its impact on somatic membrane potential despite areduction in dendritic excitability. Furthermore, therelationship between dendritic Na(+) current density and somaticexcitability is nonmonotonic, as intermediate levels of dendriticNa(+) current exert the greatest excitatory influence. Theseresults reveal that temporal shifts in dendritic spike firingprovide a novel means for backpropagating spikes to influence thefinal output of a cell.

After the completing the simulation, Fig.2B in Fernandez et al, JNP2005 is shown up.
最終更新日 Mar 22, 2013 10:49:09
作成日 Mar 16, 2011 16:06:53
登録者 NIJC管理者 (nijcadmin)
アイテムタイプ Online Simulation
更新履歴
Mar 22, 2013 Modified; Contents URL.
Feb 2, 2012 Modified; Description, Free Keywords, Simulator Name.
Mar 24, 2011 Modified; Index.
Mar 23, 2011 Modified; Preview, Simulator.
モデルコンテンツへのURL http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=59480
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